LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein
Abstract Background Human Immunodeficiency Virus-1 (HIV-1) associated neurocognitive disorders (HANDs) are accompanied by significant morbidity, which persists despite the use of combined antiretroviral therapy (cART).While activated microglia play a role in pathogenesis, changes in their immune effector functions, including phagocytosis and proinf